In 330 the capital of the Roman Empire relocated to the city Byzantium and renamed to Constantinople by its founder emperor Constantine A’. Christianity spread throughout the Empire and Saint Tryphon would later become the patron saint of winegrowers. In the millennium that the Byzantine Empire went through, a great civilization was developed, that maintained among many others things, the great tradition of grape vine growing and winemaking of the ancient Greek civilization. Throughout this period the winemaking practices have evolved and the Greek wine has continued to hold an important commercial and social role.
Christianity played an important role in the historical continuation of Greek wine through, the viticulture activities of the monasteries of Mount Athos, the use of sweet wines of the Greek islands in the communion and, the use of the vine as a key element in the Byzantine art. On the other hand, hostile raids on the mainland and piracy in the islands had disrupted viticulture periodically. Thus, despite the support from Byzantium, the Greek viticulture passed several difficulties from time to time followed by periods of recovery. However, the Aegean islands and Crete (Passos wine), hold an important position in the wine export business and in the palace of each Byzantine emperor.